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 عدد المساهمات : 231
تاريخ التسجيل : 24/02/2011
العمر : 38
 | | موضوع: Clindamycin topical solution الأربعاء أغسطس 17, 2011 12:26 pm | |
| Clindamycin topical solution
Strength: 1%
Quantity: 60 ml
Materials:
Clindamycin Hcl 150 mg. capsules …………………4 capsulesIsopropyl alcohol (or Ethanol) ……………………….42 ml.Propylene glycol ………………………………………6 ml.Water ………………………………………………….12 ml
Procedure:1- Add the *******s of four 150 mg. Clindamycin Hcl capsules to 30 ml of the solvent above; shake for 30 seconds and repeat2- 3 times for 10 to 15 minutes.2- Filter the solution, then add another 30 ml of the solvent; Shake for 30 seconds, filter, and bring the volume to 60 ml
Stability: 6 weeks
Comment:1- A solvent consisting of 20 % water v/v provides a suitable solubility for the hydrochloride salt of clindamycin.2- If the concentration of water is less than 20 %, clindamycin solubility decreases.3- If the concentration of water is greater than 20 %, appreciable amount of lactose may be precipitate out after dispensing.4- 2% solution can be prepared by the same procedure.
Clindamycin is used for the treatment of acne | |
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