Spironolactone suspension

Spironolactone suspension

Strength:2 mg/ml

Quantity: 100 ml

Materials:

Spironolactone tablet 25 mg……………..8 tablets
Sodium benzoate ………………………100 mg
Carboxymethylcellulose* 1. 5%...............20 ml
Simple syrup…………………………….40 ml
Water to ………………………………100 ml

Procedure:
Refer to the general method for suspension
compounding, (Appendix I).

Package: Amber bottle.

Storage: Refrigerate.

Label: Shake well before use.

Stability: 60 days.

References: 1, 2, 3[1], 4, 5, 15, 17, 22.

Comment: A 25 mg/ml suspension in Cherry syrup is stable for 60 days in refrigerator (Am J Health-sys Pharm Vol 53 Sp1 1996, page 73).

Spironolactone is potassium sparing antihypertensive diuretic.

Usual dosage: 1.5-3.3 mg/kg/day or 60 mg/sq.m/day in divided doses every 6-24 hours

[1] Am J Health-sys Pharm Vol 53 Oct 1 1996 page, 230