Calamine formulae

موضوع: Calamine formulae الأربعاء أغسطس 17, 2011 12:32 pm

Calamine formulae

Calamine lotion

Calamine ……………………………………………………..15 gm
Zinc oxide ……………………………………………………..5 gm
Bentonite (sterilized) ……………………………………….. 3 gm
Sodium citrate ……………………………………………… 0.5 gm
Phenol; liquefied …………………………………………….0.5gm
Glycerol ………………………………………………………..5 gm
Purified water; freshly boiled and cooled to …………......100 ml.

[1] Sterilize the bentonite by heating at not less than 160 °C.for at least 2 hours.

1- Levigate zinc oxide with glycerol.
2- Dissolve sodium citrate in about 70 ml of water.
3- Add the calamine and Bentonite gradually to the levigate.
4- Complete with water and adjust the volume.

Shake well before use; for external use.

Reference: 9, BP

Comment:

Use: soothing and protective agent.*

*The viscosity of the suspension may be increased by replacing all or part of the water by a suitable thickening agent solution like hydroxyethyl cellulose, methylcellulose, carbopol 940 (carbomer).

Calamine lotion U.S.P.

Calamine …………………………………………8 gm
Zinc oxide ………………………………………..8 gm
Glycerol ………………………………………….2 ml
Bentonite magma ………………………………..25 gm
Calcium hydroxide topical solution to …………100 ml

Refer to the general method for suspension compounding,

References: 2, 28.

Bentonite is sterilized by heating for at least 2 hours at not less than 160 ºC.

Used as antiprutitic and soothing for general allergic conditions.

Aqueous calamine cream

Calamine ………………………………… 4 gm
Zinc oxide …………………………………3 gm
Liquid paraffin …………………………….20 gm
Glyceryl monostearate …………………….5 gm
Cetomacrogol emulsifying wax …………...5 gm
Phenoxyethanol …………………………...0.5 gm
Water …………………………..…………62.5 gm

Refer to the general methods for compounding suspension. and creams

Reference: 2, 24.

Used as soothing antipruritic cream.

Calamine aqueous cream

Calamine …………………………………4 gm
Zinc oxide ………………………………..3 gm
Cetomacrogol emulsifying wax ………….6 gm
Arachis oil ……………………………….30 gm
Water to ………………………………..100 ml

1-Melt the wax with arachis oil,
2-warm about 40 ml of water to the same temperature,
3-mix the oil phase to the aqueous phase and stir until cool.
4-Triturate calamine and zinc oxide with the remainder amount of water and incorporate the formed paste into the cream

References: 9

Used as antipruritic