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عدد المساهمات : 231 تاريخ التسجيل : 24/02/2011 العمر : 37
| موضوع: Allopurinol suspension 20 mg/ml الأربعاء أغسطس 17, 2011 12:21 pm | |
| Allopurinol suspension 20 mg/ml
Quantities 100 ml. Materials Allopurinol tablets 100 mg (Zyloric®) 20 tablets Universal Vehicle to 100 ml Proceduregeneral method for suspension compounding Storage refrigerate Label Refrigerate, shake well before use. Stability 60 days References 1, 2, 3[1], 8, 9, 10, 22. Coment Allopurinol is xanthenes oxidase inhibitor used as anti-gout; uric acid lowering agent. It used in the treatment of secondary hyperuricemia that may occur during treatment of tumers, leukemia; prevention of recurrent calcium oxalate calculi.
Doses: Children < 10 years: 10 mg/kg/day in 2-3 divided doses with normal renal function. Children > 10 years and *****: 300 mg/day in divided doses.
Universal vehicle Composed of simple syrup : methyl cellulose 1 % solution in the ratio 3:7
Methycellulose 1 % solution
Methycellulose (or Carboxymethylcellulose sodium) 10 gm Sodium benzoate 2 gm Water to. 1000 ml
Dissolve sodium benzoate in about 200 ml of boiling water. Add methylcellulose powder to the boiled water and stir well for 2-3 minutes. Add the remaining amount of water (should be ice cold) carefully but quick and stir or blend well for 10 minutes. Transfer to 1 liter bottle; place on side and refrigerate overnight for at least. 4 hours until creamy thick white liquid convert to a clear gel.
[1] Am J Health Sys Pharm vol 53 Aug 15 1996 page 1994.
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